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Keep track of Intently (one)mitotane decreases amounts of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a powerful inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for probable dosage changes.Community health hazards affiliated with the five substances at